Podophylline CAS NO.9000-55-9

Jump?to:?navigation,?search??Podophyllin?is?a?resinous?powder?obtained?by?precipitating?an?alcoholic?tincture?of?the?rhizome?of?American?Mayapple?(Pod…

Jump?to:?navigation,?search??Podophyllin?is?a?resinous?powder?obtained?by?precipitating?an?alcoholic?tincture?of?the?rhizome?of?American?Mayapple?(Podophyllum?peltatum)?or?Podophyllum?emodi?by?means?of?water?acidified?with?hydrochloric?acid.?It?varies?in?color?from?grayish?to?bright?yellow?or?greenish-brown,?the?first-named?being?the?purest.?It?was?once?commonly?used?against?HPV-induced?genital?warts?because?it?contains?antiwart?lignans.?Podofilox,?a?purified?form?of?the?main?active?ingredient,?is?currently?recommended?instead?due?to?its?higher?efficacy?and?safety.[1]??The?powder?is?soluble?in?alcohol?and?strong?solutions?of?alkalis,?such?as?ammonia.?Its?composition?is?somewhat?complex.?There?are?certainly?at?least?two?resins?in?the?powder?(which?is?known?officially?as?Podophylli?resina),?one?of?them?being?soluble?and?the?other?insoluble?in?ether.?Each?of?these?contains?an?active?substance,?which?can?be?obtained?in?crystalline?form,?and?is?known?as?podophyllotoxin.?It?is?soluble?in?alcohol,?ether,?chloroform?and?boiling?water.